الأربعاء، 28 أكتوبر 2015

What different choices do individuals have for hair loss?

What different choices do individuals have for hair loss?

There ar several choices and different cosmetic treatments for hair loss. a number of these ar listed here and embrace hair-fiber powders, hairpieces, artificial wigs, human hair wigs, hair extensions, hair weaves, laser, and surgery.

Hair-fiber powders: coloured, powdery fiber sprinkles ar commercially out there and should work to camouflage hairless areas. These coloured sprinkles have special properties that facilitate them attach to hair and provides a fuller look. Toppik is one manufacturer of those product and may be found on-line. These cosmetic product ar out there while not a prescription, ar fairly cheap ($20-$40 range), and quite safe with marginal risk. typically these could also be employed in addition to medical treatments like Rogaine, Propecia, and hair transplants, and that they area unit} an excellent temporary measure to tide one over for special occasions.
Hairpieces: Among the time-honored ways that to feature hair briefly ar hairpieces or hair weaving, within which a mesh is connected to the remaining hair and artificial or human hair of comparable color and texture is woven  with existing hair. Quality varies significantly with price; conjointly, hairpieces and weaves might stretch, oxidize, and loosen.
Surgery or hair transplants: Surgical hair restoration approaches embrace numerous versions of hair transplantation (taking hair from the rear and putt it close to the front) or scalp reduction (cutting away bald areas and sewing the remainder together). Transplant procedures have improved greatly in recent years. they'll manufacture way more enticing and natural-looking results than older ways that generally leave a "checkerboard" or hair plug look. several transplant patients currently take Propecia to take care of or keep what they've transplanted. once considering a hair transplant, check the surgeon's credentials and skill fastidiously. Micrografts ar a number of the most recent techniques whereby surgeons transplant single one to 2 hair follicles. Hair transplants could also be terribly dearly-won and long procedures travel wide anyplace from $1,000-$20,000, betting on the amount of hair grafts transplanted. Typically, five hundred or additional hairs could also be transplanted in an exceedingly session

What treatment is there for hair loss in men?

What treatment is there for hair loss in men?

There are very few scientifically proven and FDA-approved treatments for hair loss. There are thousands of unproven claims and products to help with hair regrowth. Many conditioners, shampoos, vitamins, and other products claim to help hair grow in some unspecified way. Nioxin has been a popular brand of shampoo for hair loss, but there is no definite evidence showing it is any more effective than regular shampoos. These products are usually harmless but generally not scientifically proven and therefore potentially useless. To slow down hair loss, there are at least four potentially effective, basic options. These include medications like Minoxidil, and Propecia, which are for long-term use. Stopping these drugs does not seem to worsen or exacerbate the prior hair loss. The patient will simply revert to the state he would have been in had he never started treatment.
  • Minoxidil (Rogaine): This topical medication is available over the counter, and no prescription is required. It can be used in men and women. It works best on the crown, less on the frontal region. Minoxidil is available as a 2% solution, 4% solution, an extra-strength 5% solution, and a new foam or mousse preparation. Rogaine may grow a little hair, but it's better at holding onto what's still there. There are few side effects with Rogaine. The main problem with this treatment is the need to keep applying it once or twice daily, and most men get tired of it after a while. In addition, minoxidil tends to work less well on the front of the head, which is where baldness bothers most men. Inadvertent application to the face or neck skin can cause unwanted hair growth in those areas.
  • Finasteride (Propecia): This medication is FDA approved for use in only men with androgenic hair loss. Finasteride is in a class of medications called 5-alpha reductase inhibitors. It is thought to help reduce hair loss by blocking the action of natural hormones in scalp hair follicles. Propecia is a lower-dose version of a commercially available drug called Proscar that helps shrink enlarged prostates in middle-aged and older men. Women of child-bearing potential should avoid finasteride. Propecia 1 mg tablets are available by prescription and taken once daily. Propecia may grow and thicken hair to some extent for some people, but its main use is to keep (maintain) hair that's still there. Studies have shown that this medication works well in some types of hair loss and must be used for about six to 12 months before full effects are determined. This medication does not "work" in days to weeks, and its onset of visible improvement tends to be gradual. It may be best for men who still have enough hair to retain but also can help some regrow hair. Possible but very unlikely side effects include impotence or a decreased sex drive (libido). Studies have shown that these side effects were possibly slightly more common than seen in the general population and are reversible when the drug is stopped. The cost is about $70-$100/month, which is generally not reimbursed by most health insurers.
  • A group of topical medications called prostaglandin analogs have recently began undergoing testing for potential hair regrowth. They may be used in men and women. These drugs are not currently FDA approved for scalp hair loss. Currently, these are primarily used for eyelash enhancement. One of the new medications is calledbimatoprost (Latisse). Further testing and studies are required to assess the efficacy of these products in scalp hair loss. Bimatoprost solution is sometimes used off-label for help in selected cases of hair loss. It is currently FDA approved for cosmetic eyelash enhancement. Studies have shown it can treat hypotrichosis (short or sparse) of the eyelashes by increasing their growth, including length, thickness, and darkness. This medication is also commercially available as Lumigan, which is used to treat glaucoma. It is not known exactly how this medication works in hair regrowth, but it is thought to lengthen the anagen phase (active phase) of hair growth. Interestingly, during routine medical use of Lumigan eyedrops for glaucoma patients, it was serendipitously found that eyelashes got longer and thicker in many users. This led to clinical trials and the approval of cosmetic use of Latisse for eyelashes

What is traction alopecia?

What is traction alopecia?

This is atiny low or localized hair loss space caused by repetitive or persistent pull or traction on hair roots. Tight braids and ponytails will pull exhausting enough on hairs to create them fall out. If this happens, it is best to decide on hairstyles that place less tension on hair. the earlier this can be done the higher to avoid permanent injury.


What is trichotillomania?

This refers to the habit of somebody voluntarily pull at their own hairs or twisting them, typically while not realizing it. The scalp and eyelashes ar typically affected. in contrast to alopecia patches, that ar utterly swish, hair patches in cacoethes show broken-off hairs. Treatment is usually entirely behavioural. One must notice the behavior and so consciously stop. Severe or resistant cases could need stress substance with a expert or scientist or medical treatment with a specialist. many antidepressant drug or anxiety medications are shown to assist with this condition.


What is tinea capitis?

Tinea is that the medical word for zymosis, and capitis means that head. tinea is zymosis of the scalp that for the foremost half affects school-age kids. tinea is a lot of common in African or African-American scalps. This condition is rare in healthy adults. Bald spots typically show broken-off hairs and is amid a eczema. Oral antifungals will penetrate the hair roots and cure the infection, once that hair grows back. Sharing hats or combs and brushes could transmit tinea.


What is generalized (diffuse) hair loss?

This is associate degree overall hair cutting while not specific bald spots or patterns. whereas this kind of hair loss might not be noticeable to others, typically the individual can feel their hair isn't as thick or full because it antecedently was. Common conditions during this class ar

telogen emission (rapid shedding once giving birth, fever, or fulminant weight loss);

Hair loss facts

Hair loss may be a quite common condition and affects the majority at your time in their lives.
Hair loss from breakage of the hair shaft is completely different than hair loss from decreased  hair growth.
Androgenetic hair loss is seen in each men and girls however is worse in men.
Thyroid illness, anemia, supermolecule deficiency, and low sustenance levels might cause hair loss.
Alopecia areata may be a comparatively common reason behind hair loss that sometimes resolves on its own.
Medications indicated for hair regrowth embrace Rogaine (Rogaine) and finasteride (Propecia).
Prevention of hair loss includes sensible hair hygiene, regular shampooing, and sensible nutrition.
Medical health screening for hair loss might embrace blood tests like complete blood count (CBC), iron level, vitamin B, and thyroid perform tests (TFT).

الخميس، 22 أكتوبر 2015

Pluck hair in a specific pattern to grow new hair: Hair six times thicker in mice

On the off chance that there's a cure for male example sparseness, it may hurt a bit. A group drove by USC Undifferentiated organism Chief Agent Cheng-Ming Chuong has exhibited that by culling 200 hairs in a particular example and thickness, they can impel up to 1,200 substitution hairs to develop in a mouse. These outcomes are distributed in the April 9 release of the diary Cell.

"It is a decent sample of how essential exploration can prompt a work with potential translational worth," said Chuong, who is an educator of pathology at the Keck Institute of Prescription of USC. "The work prompts potential new focuses for treating alopecia, a type of balding."

The study started several years prior when first creator and going by researcher Chih-Chiang Chen touched base at USC from National Yang-Ming College and Veterans General Healing center, Taiwan. As a dermatologist, Chen realized that hair follicle damage influences its adjoining surroundings, and the Chuong lab had effectively settled that this environment thus can impact hair recovery. In view of this consolidated learning, they contemplated that they may have the capacity to utilize the earth to initiate more follicles.

To test this idea, Chen concocted a rich system to cull 200 hair follicles, one by one, in distinctive setups on the back of a mouse. While culling the hairs in a low-thickness design from a range surpassing six millimeters in measurement, no hairs recovered. Notwithstanding, higher-thickness culling from roundabout territories with measurements somewhere around three and five millimeters set off the recovery of somewhere around 450 and 1,300 hairs, including ones outside of the culled district.

Working with Arthur D. Lander from the College of California, Irvine, the group demonstrated that this regenerative procedure depends on the rule of "majority detecting," which characterizes how a framework reacts to jolts that influence some, yet not all individuals. For this situation, majority detecting underlies how the hair follicle framework reacts to the culling of some, however not all hairs.

Through sub-atomic examinations, the group demonstrated that these culled follicles sign pain by discharging incendiary proteins, which enlist safe cells to hurry to the site of the harm. These invulnerable cells then discharge flagging particles, for example, tumor rot element alpha (TNF-α), which, at a sure focus, convey to both culled and unplucked follicles that it's a great opportunity to develop hair.

"The ramifications of the work is that parallel procedures might likewise exist in the physiological or pathogenic procedures of different organs, despite the fact that they are not as effectively seen as hair recovery," said Chuong

Scientists identify proteins crucial to loss of hearing

Almost 40 million Americans suffer from hearing loss. Right now, there is no way to reverse this condition, largely because auditory hair cells, which sense sound and relay that information to the brain, do not regenerate.

A new study led by scientists at the University of Maryland School of Medicine (UM SOM) has found a key clue to how these hair cells develop. The current study identified a new role for a particular group of proteins, known as RFX transcription factors, in the development and survival of the hair cells.

"This discovery opens up new avenues, not only for understanding the genetics of hearing, but also, eventually for treating deafness," said the principal investigator, Ronna P. Hertzano, MD, PhD, Assistant Professor of Otorhinolaryngology-Head & Neck Surgery at the UM SOM.

The study appeared in the latest issue of the journal Nature Communications. The work was done in collaboration with scientists at several institutions, among them Ran Elkon, PhD, an Assistant Professor and computational biologist at the Sackler School of Medicine at Tel Aviv University in Israel.

Hertzano and her colleagues used mice whose auditory hair cells glow with a green fluorescent protein, allowing the cells to be identified from other kinds of cells. They then used next generation sequencing -- a state-of-the-art method to rapidly measure gene expression -- to sequence and quantify the thousands of genes that are expressed in hair cells, in comparison with other cells in the ear. As they generated this catalogue of genes, they were searching for key regulators of genes for hair cells. Such regulators could help researchers eventually develop techniques to regenerate hair cells. The key regulator they identified were the RFX transcription factors.

The scientists then moved on to study mice which had been genetically altered so that their hair cells lacked two of the RFX transcription factors. In these mice, hair cells initially developed normally, but then died quickly, leading to rapid hearing loss. By three months of age, the mice were profoundly deaf.

Although the experiments were done in mice, Hertzano says that it is likely that these genes work similarly in humans. Eventually, she says, it might be possible to use our increased understanding of RFX transcription factor to treat hearing loss, by either protecting hair cells from death or fostering their growth. In addition, she and her colleagues think that they will be able to identify other genes that have an important role in hair cell function.

Hertzano first got interested in the genetics of hearing as an MD-PhD student at Tel Aviv University, and then pursued residency training at the UM SOM Department of Otorhinolaryngology, where she now works as a scientist and a surgeon whose practice is focused on diseases of the ear and hearing restoration.

The current paper appeared in conjunction with another paper published in Nature Communications, by Matthew W. Kelley, PhD, a neuroscientist at the National Institute on Deafness and Other Communication Disorders. Kelley and his team also used mice with fluorescent markers in different cells of the ear followed by next generation sequencing. Rather than analyzing groups of cells, they performed a comprehensive analysis of the genes that are expressed in the different cells at a single cell resolution. Their study is the first of its kind in the ear field and helps resolved the molecular aspects of the cellular complexity of the inner ear.

الأحد، 13 سبتمبر 2015

Hair Loss in Women: How Hair Grows

This article was written specifically for women. While there is no doubt there are many men who care very much about their hair loss, severe hair loss can be a devastating experience for a woman. The fact remains that bald women are not the norm. Bald(ing) men, on the other hand, have lots of company and it’s considered perfectly normal, if not sexy, for a man to have this condition. A bald man doesn't receive a second glance.
From the author’s personal hair loss ordeal and hence the endless hours of research to resolve the issue, it can be said that:

one can find factual descriptions of the different types of hair loss but there are relatively few commonly accepted facts about the underlying causes of hair loss.
there are far too many clueless doctors who really don’t know much about hair loss but pretend they do and a lot of hair loss “experts” who disagree.

hair loss help

treatments for the matter are literally rather hit or miss affairs however there's associate endless parade of “specialists” willing to sell you their newest miracle cure.
in general, there area unit a huge quantity of contradictions relating to the whole subject.
Despite all this, it's best to learn of the facts that area unit out there, and therefore the additional someone affected by hair loss reads and learns regarding the matter, the quicker it'll be to regulate or cure it. Of course, to grasp hair loss, it's vital to initial perceive however hair grows.

How Hair Grows 
A human scalp has around a hundred,000 hair follicles; someone is born with the full range of follicles they'll have throughout their life. Blondes usually have the foremost hair, averaging one hundred forty,000 hairs, brunettes and folks with black hair regarding one hundred ten,000 hairs and redheads regarding ninety,000 hairs. Hair grows regarding .3 to .4mm per day, 1/2 in. per month or around six inches per year.


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While hair itself is made up of extruded, compacted dead cells, the scalp is composed of living follicles. Each hair follicle has four distinct phases it cycles through on a regular basis:
  1. Anagen is the active or growth phase (which can actually be subdivided further into the proanagen, mesanagen and metanagen phases). Approximately 85% of the scalp's hairs are in this phase at any one time. The phase for each anagen hair lasts from two to six years.
  2. Catagen is the transition phase in which hairs begin to break down and lasts from one to two weeks.
  3. Telogen is the resting phase in which hairs prepare to shed. Typically 10% to 15% of the scalp’s hairs are in this phase at any one time. This phase lasts from two to four months.
  4. Ketogen, an only recently recognized fourth phase, occurs between the Telogen and new Anagen phase (depicted in the 4th box, "Return to Anagen"). This new phase is the period during which the hair follicle appears empty until the new hair protrudes from the scalp.


Alopecia areata (AA) is believed to be a symptom of an autoimmune disorder that occurs when a person’s immune system mistakenly attacks the hair follicles. Hair loss may result in clumps of hair falling out, leaving round, shiny, smooth bald spots on the scalp. If the hair loss causes a person to go bald, the disorder is then called alopecia totalis; hair loss over the entire body is referred to asalopecia universalis. Hair regrowth depends on the severity of the loss. For some people, hair will grow back within a matter of months or years while others may endure fluctuating hair regrowth and loss for the rest of their lives.
Anagen is that the active or growth part (which will truly be divided any into the proanagen, mesanagen and metanagen phases). more or less eighty fifth of the scalp's hairs area unit during this part at anyone time. The part for every anagen hair lasts from 2 to 6 years.
Catagen is that the transition introduce that hairs begin to interrupt down and lasts from one to 2 weeks.
Telogen is that the resting introduce that hairs prepare to shed. generally 100% to fifteen of the scalp’s hairs area unit during this part at anyone time. This part lasts from 2 to four months.
Ketogen, associate solely recently recognized fourth part, happens between the Telogen and new Anagen part (depicted within the fourth box, "Return to Anagen"). This new part is that the amount throughout that the follicle seems empty till the new hair protrudes from the scalp.
A full cycle will last anyplace from 2 to seven years per vesicle, and every vesicle can complete between ten to twenty cycles during a life. however once hair follicles become stuck within the Telogen part, uncommon hair loss and/or dilution happens. Losing fifty to a hundred hairs per day is ...normal; losing over a hundred hairs per day might indicate the presence of a hair loss downside.